From Next-Generation Sequencing

to Translational Medicine

in Neurological Disease Research

25th–27th July 2016  |  Tübingen, Germany

SCOPE

Identifying disease-causing genes represents a major focus in current medical genetics research, and next-generation sequencing technology is profoundly changing the way of diagnostics and therapeutics. Coping with the underlying informational complexity requires multidisciplinary efforts that generate synergies through cross-disciplinary research at the nexus of medicine, biology, and informatics.

 

With this Summer School, we address precisely this challenge and cover the entire process from clinical phenotyping, to NGS data analysis, to clinical and genetic follow-ups, to functional validations in model systems, and to finally guide development of therapies and (personalized) clinical applications.

 

In particular, we will focus on neurological disorders like Parkinson’s disease, dystonias, ataxias, and related brain disorders by analyzing genomic NGS data from patients during hands-on workshops and showing examples of how to translate research findings into the clinic.

 

This Summer School is tailored for PhD students and PostDocs working in the field of biology, neuroscience, biochemistry, experimental medicine, and bioinformatics as well as clinicians, particularly medical doctors at the beginning of their specialization.

 

Participants of the 3-day-event held in English will receive 3 ECTS credit points according to the European Credit Transfer System for their attendance of the Summer School and presentation of a poster.

The Summer School is generously supported by the Institutional Strategy of the University of Tübingen through funds from the Excellence Initiative (DFG, ZUK 63) and will be organized and hosted by the Institute of Medical Genetics and Applied Genomics at the University Hospital Tübingen

SPEAKERS

KEYNOTE LECTURE

Genetic History of Europe – Migration and adaptation in prehistory

Johannes Krause

Max Planck Institute for the Science of Human History

Department of Archaeogenetics

Jena, Germany

Ancient DNA can reveal pre-historical events that are difficult to discern through the study of archaeological remains and modern genetic variation alone. Our research team analyzed more than 200 ancient human genomes spanning the last 10,000 years of Western Eurasian pre-history. We find direct evidence for two major genetic turnover events at the beginning and at the end of the Neolithic time period in Europe. Our data provide strong support of a major migration of early farmers spreading from Anatolia starting around 9000 years ago bringing agriculture and domestic animals to Europe. Following their arrival, early farmers genetically admix with indigenous Europeans in the course of the coming 3000 years. At the end of the Neolithic period, around 5000 years ago, we find the first genetic evidence for another major migration event of people from the pontic steppe, north of the black sea, into the heartland of Europe. The newcomers practice pastoralism, are highly mobile, due to the widespread use of horses, wheels and wagons and they may be responsible for the first spread of plague among human populations in Eurasia. We find that all modern European populations today are a genetic mixture of steppe pastoralist, early farmers and indigenous European hunter-gatherers in varying proportions. We furthermore find that due to genetic mixture and local biological adaptation there are major changes in human phenotypes such as eye color, skin color and the ability to digest milk sugar through the course of the last 10,000 years.

The program is subject to change without notice!

PROGRAM

REGISTRATION

There is a non-refundable registration fee of EUR 250 per participant. The fee becomes due upon notification of acceptance that will be sent out by June 20th and has to be paid by wire transfer to the account mentioned in the acceptance letter. Participation is guaranteed only when the full payment is received by July 3, 2016.

 

Registration includes:

  • Attendance at all sessions and workshops
  • Lunches (MON – WED)
  • Dinners (MON – TUE)
  • All tea & coffee breaks
  • Social events including a guided walk through the old town of Tübingen and a boat tour on the Neckar river

Accommondation Grants

In general, all participants of the Summer School will have to arrange and book travel and accommodation on their own. For doctoral students from outside Tübingen, we offer 10 Accommodation Grants covering a 3-night-stay. Recipients of these grants will be selected based on their application documents, in particular on the submitted abstract and motivation letter. Doctoral students who will receive a grant must present a poster.

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The Summer School addresses PhD students and PostDocs working in the fields of biology, neuroscience, biochemistry, experimental medicine, and bioinformatics as well as clinicians, particularly medical doctors at the beginning of their specialization

25 participants will be selected by the steering committee upon emailing the completed application form

REGISTER TODAY

Please apply by emailing the completed application form below to Dr. Carola Reinhard by May 27, 2016: carola.reinhard(at)med.uni-tuebingen.de

 

3 ECTS credit points will be granted to participants for attendance and presentation of a poster. CME credit points for physicians available, too.

Institute of Medical Genetics and Applied Genomics

Institute of Medical Genetics and Applied Genomics

  • Prof. Dr. Olaf Rieß
  • Dr. Julia Schulze-Hentrich
  • Dr. Marc Sturm
  • Florian Harmuth
  • Dr. Thorsten Schmidt
  • Dr. Stephan Waldmüller
  • Dr. Jeannette Hübener-Schmid
  • Dr. Carola Reinhard
    Tel: +49-7071-29 72191
    carola.reinhard(at)med.uni-tuebingen.de

 

  • Dr. Birte Zurek
    Tel: +49-7071-29 72285
    birte.zurek(at)med.uni-tuebingen.de

Research Management

Institute of Medical Genetics and Applied Genomics

University Hospital Tübingen

Calwerstr. 7

72076 Tübingen, Germany

Organizers & Contact

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Scientific Organizing Committee

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CONTACT

WELCOME to Tübingen

About Tübingen

 

The Swabian university town of 86,000 inhabitants and 27,000 students combines the flair of a lovingly restored medieval town with the vibrant and cosmopolitan atmosphere of a students' city. Numerous sidewalk cafés, cozy student pubs, restaurants, and taverns invite visitors all year round. Taking a boat trip in one of the famous „Stocherkahn“ – the boat type exclusive and native to Tübingen navigated by a long wooden pole – offers a scenic view of the picturesque Neckar waterfront with the famous Hölderlin Tower, and numerous attractions nearby await to be seen.

Meeting venue

 

Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen. Located in the Women’s Hospital (Frauenklinik), Calwerstr. 7, 72076 Tübingen, Germany. Plese see map below and link here.

 

The Summer School will be held in the seminar room 305 on 5th floor, Calwerstr. 7, 72076 Tübingen. The workshops will be held at the Centre for Data Processing (Zentrum für Datenverarbeitung, ZDV) room K2 on the 2nd floor, Wächterstr. 76, 72074 Tübingen.

 

Transportation

 

  • By train to Tübingen main station. Tübingen's main station is centrally located on the southern side of the town centre. It is well connected to the ICE train station Stuttgart. For more information please check: www.bahn.de
  • By plane to Stuttgart airport (STR). The airport sprinter shuttle 828 connects Stuttgart airport with Tübingen, total duration: ~1h, costs: 6.80 EUR one way, timetable available here.
  • By car. Tübingen is located on the intersection of the B27 and B28 and has fast connections to the A8 (Munich-Stuttgart) and the A81 (Singen-Heilbronn). There is paid on-site parking available. We do however recommend to arrive by public transport and leave your car at the hotel.

 

Accommodation

 

  • Tübingen offers a great variety of places to stay, from hotels to guest houses you will receive a warm welcome and enjoy a family-like ambiance. A comprehensive overview of all accommodations can be found here.
  • A contingent of rooms has been reserved for recipients of the travel grants at Hotel Hospiz.

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